Charles Blake was born in Reading in Berkshire, the son of John Blake, gentleman of that town, and his wife, Mary the daughter of Richard Winch of both Reading and Fifield House in Bray. He was educated at the Merchant Taylors' School and St. John's College, Oxford, of which he was scholar and afterwards fellow (BA 1683, MA 1687-8, DD 1696). Blake became domestic chaplain to Sir William Dawes, afterwards Bishop of Chester and Archbishop of York, who was his close friend. Among his preferments were the rectory of St. Sepulchre's, London, of Wheldrake in Yorkshire, and of St. Mary's, Hull, and he was successively a prebendary of Chester, a prebendary of York (1716) and Archdeacon of York (1720). He died on 22nd November 1730.

Blake published a small collection of Latin verses, consisting of a translation into Latin of the poem of Musaeus on Hero and Leander, and of part of the fifth book of Milton's 'Paradise Lost' and two original poems, one called 'Hibernia Plorans' written in 1689, the year of the Siege of Londonderry, deploring Ireland's woes, in the style of Virgil's Eclogues; and the other an elegy on the death, in 1688, of Frederick, the Great Elector of Brandenburg. These were all published together in a little sixpenny pamphlet, under the title of 'Lusus Amatorius, sive Musaei de Herone et Leandro carmen; cui accedunt Tres Nugae Poeticae' at London in 1693.